/* ================= InVivo Biomarker Console — design system ================= */
:root{
  --bg:#0f1420; --bg2:#151c2c; --surface:#ffffff; --ink:#1a2233; --ink-soft:#54617a;
  --line:#e6eaf2; --line-2:#eef1f7; --muted:#7b8aa5;
  --brand:#2f6df6; --brand-2:#5b8def; --brand-ink:#1b4bcf;
  --teal:#12b3a6; --violet:#7c5cff; --amber:#f0a92b; --rose:#f0596a; --green:#22b573;
  --min:#0e9f8f; --max:#6b5cff;
  --shadow:0 1px 2px rgba(16,24,40,.06),0 8px 24px -12px rgba(16,24,40,.18);
  --shadow-lg:0 24px 60px -22px rgba(16,24,40,.42);
  --r:14px; --r-sm:10px; --r-lg:20px;
  --sans:'Inter',system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif;
}
*{box-sizing:border-box}
html,body{margin:0;padding:0}
body{
  font-family:var(--sans); color:var(--ink); background:#f4f6fb;
  -webkit-font-smoothing:antialiased; line-height:1.5; font-size:15px;
}
a{color:var(--brand-ink);text-decoration:none} a:hover{text-decoration:underline}
h1,h2,h3,h4{margin:0 0 .4em;line-height:1.2;font-weight:700;letter-spacing:-.01em}
h1{font-size:1.7rem} h2{font-size:1.25rem} h3{font-size:1.05rem}
p{margin:0 0 .8em} img{max-width:100%}
.muted{color:var(--muted)} .small{font-size:.82rem} .tiny{font-size:.72rem}
.center{text-align:center} .right{text-align:right} .nowrap{white-space:nowrap}
.mono{font-family:ui-monospace,SFMono-Regular,Menlo,monospace}

/* ---------- layout ---------- */
.app{display:flex;min-height:100vh}
.sidebar{
  width:248px;flex:0 0 248px;background:linear-gradient(180deg,#111a2e,#0d1524);
  color:#c7d2e6;padding:18px 14px;position:sticky;top:0;height:100vh;overflow-y:auto
}
.brand{display:flex;align-items:center;gap:10px;padding:6px 8px 16px;color:#fff}
.brand .logo{width:38px;height:38px;border-radius:11px;display:grid;place-items:center;
  background:linear-gradient(135deg,var(--brand),var(--violet));font-weight:800;color:#fff;
  box-shadow:0 6px 18px -6px rgba(124,92,255,.7)}
.brand b{font-size:1.02rem;letter-spacing:-.02em;display:block;line-height:1.1}
.brand span{font-size:.68rem;color:#8ea0c0;letter-spacing:.14em;text-transform:uppercase}
.nav{display:flex;flex-direction:column;gap:2px;margin-top:8px}
.nav .lbl{font-size:.66rem;letter-spacing:.16em;text-transform:uppercase;color:#61708f;margin:16px 10px 6px}
.nav a{display:flex;align-items:center;gap:11px;padding:9px 11px;border-radius:10px;color:#c2cee2;
  font-weight:500;font-size:.92rem;transition:.15s}
.nav a svg{width:18px;height:18px;opacity:.85;flex:0 0 18px}
.nav a:hover{background:rgba(255,255,255,.06);color:#fff;text-decoration:none}
.nav a.active{background:linear-gradient(90deg,rgba(47,109,246,.22),rgba(124,92,255,.14));
  color:#fff;box-shadow:inset 0 0 0 1px rgba(124,150,255,.25)}
.side-foot{margin-top:auto;padding:14px 8px 4px;border-top:1px solid rgba(255,255,255,.07)}
.userchip{display:flex;align-items:center;gap:10px;color:#dbe4f4}
.userchip .av{width:34px;height:34px;border-radius:50%;background:linear-gradient(135deg,#2f6df6,#12b3a6);
  display:grid;place-items:center;color:#fff;font-weight:700;font-size:.8rem}

.main{flex:1;min-width:0;display:flex;flex-direction:column}
.topbar{display:flex;align-items:center;gap:16px;padding:14px 26px;background:rgba(255,255,255,.9);
  backdrop-filter:blur(8px);border-bottom:1px solid var(--line);position:sticky;top:0;z-index:20}
.topbar .page-t{font-weight:700;font-size:1.05rem}
.content{padding:26px;max-width:1240px;width:100%;margin:0 auto}
.mobile-only{display:none}

/* ---------- search box ---------- */
.searchbox{position:relative;flex:1;max-width:560px}
.searchbox input{width:100%;padding:11px 14px 11px 40px;border:1px solid var(--line);border-radius:12px;
  font-size:.95rem;background:#fff;transition:.15s;font-family:inherit}
.searchbox input:focus{outline:none;border-color:var(--brand-2);box-shadow:0 0 0 4px rgba(47,109,246,.12)}
.searchbox .ic{position:absolute;left:13px;top:50%;transform:translateY(-50%);color:var(--muted);width:18px;height:18px}
.suggest{position:absolute;top:calc(100% + 6px);left:0;right:0;background:#fff;border:1px solid var(--line);
  border-radius:12px;box-shadow:var(--shadow-lg);overflow:hidden;z-index:60;display:none}
.suggest.open{display:block}
.suggest a{display:flex;align-items:center;justify-content:space-between;gap:10px;padding:10px 14px;color:var(--ink)}
.suggest a:hover,.suggest a.hi{background:#f2f6ff;text-decoration:none}
.suggest .st{font-size:.66rem;text-transform:uppercase;letter-spacing:.08em;padding:2px 7px;border-radius:6px;
  background:#eef2fb;color:#5a6b8c;font-weight:700}

/* ---------- reusable autocomplete ---------- */
.ac-wrap{position:relative;display:block}
.ac-menu{position:absolute;top:calc(100% + 6px);left:0;right:0;background:#fff;border:1px solid var(--line);
  border-radius:12px;box-shadow:var(--shadow-lg);overflow:hidden auto;z-index:80;display:none;max-height:340px}
.ac-menu.open{display:block}
.ac-menu a{display:flex;align-items:center;justify-content:space-between;gap:10px;padding:10px 14px;color:var(--ink)}
.ac-menu a:hover,.ac-menu a.hi{background:#f2f6ff;text-decoration:none}
.ac-menu .st{font-size:.62rem;text-transform:uppercase;letter-spacing:.07em;padding:2px 7px;border-radius:6px;
  background:#eef2fb;color:#5a6b8c;font-weight:700;margin-right:8px}

/* ---------- cards / panels ---------- */
.card{background:var(--surface);border:1px solid var(--line);border-radius:var(--r);box-shadow:var(--shadow)}
.card.pad{padding:20px}
.card-h{padding:16px 20px;border-bottom:1px solid var(--line-2);display:flex;align-items:center;gap:10px;justify-content:space-between}
.card-b{padding:20px}
.grid{display:grid;gap:16px}
.g2{grid-template-columns:repeat(2,1fr)} .g3{grid-template-columns:repeat(3,1fr)} .g4{grid-template-columns:repeat(4,1fr)}
.split{display:grid;grid-template-columns:1fr 320px;gap:20px;align-items:start}
.stack{display:flex;flex-direction:column;gap:16px}
.row{display:flex;gap:12px;flex-wrap:wrap;align-items:center}

/* ---------- stat tiles ---------- */
.stat{display:flex;align-items:center;gap:14px;padding:18px;border-radius:var(--r);background:#fff;
  border:1px solid var(--line);box-shadow:var(--shadow)}
.stat .ico{width:46px;height:46px;border-radius:13px;display:grid;place-items:center;color:#fff}
.stat .n{font-size:1.6rem;font-weight:800;letter-spacing:-.02em;line-height:1}
.stat .l{color:var(--muted);font-size:.82rem;margin-top:2px}
.bg-brand{background:linear-gradient(135deg,#2f6df6,#5b8def)}
.bg-teal{background:linear-gradient(135deg,#0fb5a6,#38d0b6)}
.bg-violet{background:linear-gradient(135deg,#7c5cff,#a58bff)}
.bg-amber{background:linear-gradient(135deg,#f0a92b,#ffca5f)}
.bg-rose{background:linear-gradient(135deg,#f0596a,#ff89a0)}
.bg-green{background:linear-gradient(135deg,#1fae6c,#4bd894)}

/* ---------- badges / chips ---------- */
.badge{display:inline-flex;align-items:center;gap:5px;padding:3px 9px;border-radius:999px;font-size:.72rem;
  font-weight:700;letter-spacing:.01em;background:#eef2fb;color:#4c5c7d;line-height:1.4;white-space:nowrap}
.badge.min{background:rgba(14,159,143,.13);color:#0b7f72}
.badge.max{background:rgba(107,92,255,.13);color:#5a48d6}
.badge.ext{background:rgba(240,169,43,.16);color:#a9730b}
.badge.ok{background:rgba(34,181,115,.14);color:#128a53}
.badge.warn{background:rgba(240,169,43,.16);color:#a9730b}
.badge.err{background:rgba(240,89,106,.14);color:#c33648}
.badge.brand{background:rgba(47,109,246,.13);color:#1b4bcf}
.chip{display:inline-flex;align-items:center;gap:7px;padding:6px 12px;border-radius:999px;background:#fff;
  border:1px solid var(--line);font-size:.84rem;font-weight:600;color:var(--ink-soft)}
.chip:hover{border-color:var(--brand-2);color:var(--brand-ink);text-decoration:none}
.chip.on{background:var(--brand);color:#fff;border-color:var(--brand)}
.pill-org{font-size:.7rem;color:var(--muted);font-weight:700;letter-spacing:.06em;text-transform:uppercase}

/* ---------- buttons ---------- */
.btn{display:inline-flex;align-items:center;gap:8px;padding:10px 16px;border-radius:11px;border:1px solid transparent;
  font-weight:600;font-size:.9rem;cursor:pointer;font-family:inherit;transition:.15s;background:#fff;color:var(--ink)}
.btn svg{width:17px;height:17px}
.btn:hover{text-decoration:none}
.btn-primary{background:linear-gradient(135deg,var(--brand),var(--brand-2));color:#fff;
  box-shadow:0 8px 18px -8px rgba(47,109,246,.7)}
.btn-primary:hover{filter:brightness(1.05)}
.btn-ghost{background:#fff;border-color:var(--line);color:var(--ink-soft)}
.btn-ghost:hover{border-color:var(--brand-2);color:var(--brand-ink)}
.btn-dark{background:var(--ink);color:#fff}
.btn-danger{background:#fff;border-color:#f3c0c6;color:#c33648}
.btn-danger:hover{background:#fff5f6}
.btn-sm{padding:7px 12px;font-size:.82rem;border-radius:9px}
.btn-block{width:100%;justify-content:center}

/* ---------- tables ---------- */
.table-wrap{overflow-x:auto;border-radius:var(--r);border:1px solid var(--line)}
table.tbl{width:100%;border-collapse:collapse;background:#fff;font-size:.9rem}
table.tbl th{text-align:left;padding:11px 14px;background:#f7f9fd;color:#5a6b8c;font-weight:700;font-size:.74rem;
  text-transform:uppercase;letter-spacing:.05em;border-bottom:1px solid var(--line)}
table.tbl td{padding:11px 14px;border-bottom:1px solid var(--line-2);vertical-align:top}
table.tbl tr:last-child td{border-bottom:none}
table.tbl tr:hover td{background:#fafcff}

/* ---------- forms ---------- */
.field{margin-bottom:14px}
.field label{display:block;font-weight:600;font-size:.82rem;color:var(--ink-soft);margin-bottom:6px}
.input,select,textarea{width:100%;padding:10px 13px;border:1px solid var(--line);border-radius:10px;font-size:.92rem;
  font-family:inherit;background:#fff;color:var(--ink);transition:.15s}
.input:focus,select:focus,textarea:focus{outline:none;border-color:var(--brand-2);box-shadow:0 0 0 4px rgba(47,109,246,.1)}
textarea{resize:vertical;min-height:90px;line-height:1.5}

/* ---------- selectable biomarker rows ---------- */
.pick{display:flex;gap:12px;align-items:flex-start;padding:12px 14px;border:1px solid var(--line);border-radius:12px;
  background:#fff;transition:.12s;cursor:pointer;position:relative}
.pick:hover{border-color:var(--brand-2);box-shadow:0 6px 16px -10px rgba(47,109,246,.5)}
.pick.checked{border-color:var(--brand);background:linear-gradient(0deg,rgba(47,109,246,.05),rgba(47,109,246,.05))}
.pick input{margin-top:3px;width:18px;height:18px;accent-color:var(--brand);flex:0 0 18px}
.pick .bm-name{font-weight:700;font-size:.92rem}
.pick .bm-meta{color:var(--muted);font-size:.78rem;margin-top:1px}
.panel-col-h{display:flex;align-items:center;gap:8px;font-weight:700;font-size:.82rem;text-transform:uppercase;
  letter-spacing:.05em;color:var(--ink-soft);margin-bottom:10px}

/* ---------- interpretation output ---------- */
.readout{border-left:3px solid var(--brand);background:#f7faff;border-radius:0 12px 12px 0;padding:14px 16px;margin-bottom:12px}
.readout h4{margin:0 0 4px;font-size:.98rem}
.readout .give{color:var(--ink-soft);font-size:.88rem;margin:0 0 6px}
.readout .chg{font-size:.86rem;color:#3a475f;background:#fff;border:1px solid var(--line-2);border-radius:8px;padding:8px 10px}
.meter{height:9px;border-radius:999px;background:#eef1f7;overflow:hidden}
.meter > i{display:block;height:100%;border-radius:999px;background:linear-gradient(90deg,var(--brand),var(--teal))}
.axis{display:flex;justify-content:space-between;align-items:center;padding:7px 0;border-bottom:1px dashed var(--line-2)}
.axis:last-child{border-bottom:none}

.rec{display:flex;align-items:flex-start;gap:10px;padding:10px 12px;border-radius:10px;background:#fff;border:1px solid var(--line)}
.rec:hover{border-color:var(--brand-2)}
.rec .dot{width:8px;height:8px;border-radius:50%;background:var(--violet);margin-top:6px;flex:0 0 8px}

.hero{background:linear-gradient(120deg,#16213b,#1d2c4d 55%,#25406e);color:#fff;border-radius:var(--r-lg);
  padding:30px 30px;position:relative;overflow:hidden}
.hero:after{content:"";position:absolute;right:-60px;top:-60px;width:260px;height:260px;border-radius:50%;
  background:radial-gradient(circle,rgba(124,92,255,.5),transparent 70%)}
.hero h1{color:#fff;font-size:1.9rem} .hero p{color:#c3d0ea;max-width:640px}
.hero .searchbox input{background:rgba(255,255,255,.96)}

.empty{text-align:center;padding:50px 20px;color:var(--muted)}
.empty svg{width:52px;height:52px;opacity:.4;margin-bottom:10px}

.flash{padding:12px 16px;border-radius:11px;margin-bottom:16px;font-weight:600;font-size:.9rem;display:flex;gap:10px;align-items:center}
.flash.ok{background:#e9f9f0;color:#128a53;border:1px solid #b8ecce}
.flash.err{background:#fdeef0;color:#c33648;border:1px solid #f4c4cb}

.crumbs{display:flex;gap:6px;align-items:center;color:var(--muted);font-size:.82rem;margin-bottom:14px}
.crumbs a{color:var(--muted)} .crumbs a:hover{color:var(--brand-ink)}

.tag-list{display:flex;flex-wrap:wrap;gap:7px}
.kbd{font-family:ui-monospace,monospace;font-size:.72rem;background:#eef2fb;border:1px solid #dbe3f2;border-bottom-width:2px;
  border-radius:6px;padding:1px 6px;color:#4c5c7d}

/* ---------- print header (screen-hidden) ---------- */
.print-head{display:none}

/* ---------- responsive ---------- */
@media(max-width:1080px){ .split{grid-template-columns:1fr} .g4{grid-template-columns:repeat(2,1fr)} }
@media(max-width:860px){
  .sidebar{display:none}
  .mobile-only{display:flex}
  .g3,.g4,.g2{grid-template-columns:1fr}
  .content{padding:16px}
  .topbar{padding:12px 14px;gap:10px}
  .searchbox{max-width:none}
}

/* ================= A4 PRINT ================= */
@media print{
  @page{size:A4;margin:14mm 12mm}
  body{background:#fff;font-size:11.5pt;color:#000}
  .sidebar,.topbar,.no-print,.btn,.suggest,.searchbox,.side-foot{display:none !important}
  .app,.main,.content{display:block;padding:0;margin:0;max-width:none}
  .card{border:1px solid #ccc;box-shadow:none;break-inside:avoid}
  .split{display:block}
  .print-head{display:block;border-bottom:2px solid #16213b;padding-bottom:8px;margin-bottom:14px}
  .print-head .pt{font-size:16pt;font-weight:800;color:#16213b}
  .print-head .ps{font-size:9pt;color:#555}
  .readout{background:#f6f6f6 !important;-webkit-print-color-adjust:exact;print-color-adjust:exact}
  .badge{border:1px solid #ccc;-webkit-print-color-adjust:exact;print-color-adjust:exact}
  a{color:#000;text-decoration:none}
  .grid,.g2,.g3{display:block}
  .card,.readout{margin-bottom:10px}
  h1{font-size:16pt} h2{font-size:13pt}
}